HCID 69507074, compound → HCID 69507151, compound

Participants

Reaction Steps

The general method described in Part G of Example 6 was followed using 5-(7-phenyl-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)pentan-2-one (1.0 g, 2.69 mmol) in lieu of N-methoxy-N-[4-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]acetamide. Recrystallization from hot methanol and water afforded 0.1815 g of 5-(4-amino-7-phenyl-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)pentan-2-one as a tan powder, mp 202-204° C. MS (APCI) m/z 387.1 (M+H+); Anal. calcd for C24H26N4O 0.66H2O: C, 72.36; H, 6.91; N, 14.06. Found: C, 64.95; H, 7.78; N, 17.92.C24H26N4O 0.66H2O Exact Mass: Theor. Mass: 387.2185 Da. Meas. Mass: 387.2191 Da. Mass Dev. 1.5 ppm.

Provenance & Evidence