Hydrochloric Acid → HCID 86612259, compound

Participants

Reaction Steps

The preparation of tert-butyl 4-(4-amino-6,7-dimethyl-2-propyl-1H-imidazo[4,5-c]pyridin-1-yl)butyl[(tert-butoxycarbonyl)oxy]carbamate is described in Parts A-F of Example 14. A mixture of 4M hydrochloric acid in dioxane (2.25 mL, 9.0 mmol, 20 eq) was added to a solution of tert-butyl 4-(4-amino-6,7-dimethyl-2-propyl-1H-imidazo[4,5-c]pyridin-1-yl)butyl[(tert-butoxycarbonyl)oxy]carbamate (0.22 g, 0.45 mmol, 1 eq) in dichloromethane (5 mL) and stirred for 2 hours. The reaction mixture was concentrated under reduced pressure and the resulting white solid was concentrated from chloroform and dried under vacuum to provide N-[4-(4-amino-6,7-dimethyl-2-propyl-1H-imidazo[4,5-c]pyridin-1-yl)butyl]hydroxylamine.

Provenance & Evidence