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Triethylamine → [3-(2-Methyl-[1,3]dioxolan-2-yl)propyl](3-nitro-quinolin-4-yl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine | HCID 560007 | — |
| 反応物 | 4-Chloro-3-nitroquinoline | HCID 11275808 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | [3-(2-Methyl-[1,3]dioxolan-2-yl)propyl](3-nitro-quinolin-4-yl)amine | HCID 69506985 | 64.3% |
反応手順
The general method described in Part A of Example 28 was used to react 4-chloro-3-nitroquinoline (45.0 g, 216 mmol), 3-(2-methyl-[1,3]dioxolan-2-yl)propylamine (37.0 g, 255 mmol, prepared as described in PCT Publication WO 01/51486) and triethylamine (37.0 g, 366 mmol) in dichloromethane for 15 hours to provide [3-(2-methyl-[1,3]dioxolan-2-yl)propyl]-(3-nitroquinolin-4-yl)amine (44.1 g) as a yellow solid after recrystallization from a toluene/hexane mixture.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08778963B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-4be060e1467746379c08e2b7fbe2d487 |
| 出典メモ | uspto-grants-2014_07 |