Benzyloxyamine hydrochloride → HCID 86612261, compound

Participants

Reaction Steps

By the general methods described in Example 35, 5-(4-amino-2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)pentan-2-one was reacted with O-benzylhydroxylamine hydrochloride to provide 5-(4-amino-2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)pentan-2-one O-benzyloxime hydrochloride in about a 16 to 1 mixture of E and Z isomers as a white solid after recrystallization of the hydrochloride salt from a mixture of toluene and methanol, mp 184-186° C.

Provenance & Evidence