O-Methylhydroxylamine hydrochloride → HCID 72448488, compound

Participants

Reaction Steps

By the general method of Part F in Example 30, 5-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)-4,4-dimethylpentan-2-one was reacted with O-methylhydroxylamine hydrochloride to provide 5-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)-4,4-dimethylpentan-2-one O-methyloxime as about a 49 to 1 mixture of E and Z isomers as a yellow solid after recrystallization from aqueous methanol, mp 196-198° C. MS (APCI) m/z 368 (M+H)+; Anal. calcd for C21H29N5O: C, 68.63; H, 7.95; N, 19.06. Found: C, 68.69; H, 7.66; N, 19.04.

Provenance & Evidence