O-Methylhydroxylamine hydrochloride → HCID 72448487, compound

Participants

Reaction Steps

By the general method described in Part F of Example 30, 5-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)-4,4-dimethylpentan-2-one was reacted with O-methylhydroxylamine hydrochloride to provide 5-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)-4,4-dimethylpentan-2-one O-methyloxime as about a 2.9 to 1 mixture of E and Z isomers as a tan solid after recrystallization from aqueous methanol, mp 148-150° C.

Provenance & Evidence