Hydrochloric Acid → HCID 86612264, compound

Participants

Reaction Steps

A mixture of N-[4-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-N-[(tert-butoxycarbonyl)oxy]-2,2-dimethylpropanamide (3.35 g, 6.52 mmol), dichloromethane (50 mL), and 4 M HCl in dioxane (13.0 mL, 52.2 mmol) was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure. The residue was concentrated twice from dichloromethane (2×25 mL) to provide 1-[4-(hydroxyamino)butyl]-2-propyl-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride.

Provenance & Evidence