o-Toluenesulfonyl chloride → HCID 69507195, compound

Participants

Reaction Steps

4-(2-Propyl-1H-imidazo[4,5-c]quinolin-1-yl)butan-1-ol (7.27 g, 25.7 mmol, which can be prepared using the method described in Example 43 Part A) was oxidized and then animated using a modification of the general method described in Example 4 Part H. The oxidation was run in chloroform in lieu of dichloromethane and the crude N-oxide was isolated prior to being dissolved in dichloromethane and treated with ammonium hydroxide and toluene sulfonyl chloride. 3.82 g of 4-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butan-1-ol was obtained.

Provenance & Evidence