反应详情

温度

95 °C

A mixture of 5-chloro-2-fluoro-4-iodopyridine (517 mg, 2.008 mmol), tert-butyl (trans-4-aminocyclohexyl)methylcarbamate (550 mg, 2.410 mmol), DMSO (2 ml) and TEA (0.336 ml, 2.410 mmol) reaction mixture was stirred at about 95° C. for about 26 hours. The crude reaction mixture was cooled to room temperature, mixed with 125 ml ethyl acetate, washed with saturated sodium bicarbonate (2×), water (3×), saturated salt solution (1×), dried sodium sulfate, filtered and concentrated under reduced pressure to yield a residue. The residue was purified by silica gel chromatography using a 40 g column, eluting from 0%-35% ethyl acetate with hexane. The desired fractions were concentrated to constant mass, yielding 656 mg of titled compound as free base. LCMS (m/z): 466.1 (MH+), retention time=0.93 min.

1. customThe crude reaction mixture
2. temperaturewas cooled to room temperature
3. washwashed with saturated sodium bicarbonate (2×), water (3×), saturated salt solution (1×), dried sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure
6. customto yield a residue
7. customThe residue was purified by silica gel chromatography
8. washeluting from 0%-35% ethyl acetate with hexane
9. concentrationThe desired fractions were concentrated to constant mass