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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1623441Generated: October 31, 2026

4-Iodobenzonitrile → 3-{3-[1-(4-Cyano-phenyl)-1-phenyl-meth-(E)-ylidene]-2-oxo-2,3-dihydro-indol-1-ylmethyl}-benzoic acid methyl ester

https://huagongshe.com/reaction/1623441

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-IodobenzonitrileHCID 76467—
Reactant3-{[Phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl esterHCID 67036155—
Product3-{3-[1-(4-Cyano-phenyl)-1-phenyl-meth-(E)-ylidene]-2-oxo-2,3-dihydro-indol-1-ylmethyl}-benzoic acid methyl esterHCID 51033548—

Reaction Steps

The title compound was prepared in analogy to Example 5 starting from 4-iodo-benzonitrile (commercially available) and 3-{[phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (CDCl3, 300 MHz) δppm 8.00 (s, 1H), 7.93 (d, 1H), 7.74-7.76 (m, 2H), 7.35-7.51 (m, 9H), 7.10 (t, 1H), 6.56-6.72 (m, 2H), 6.35 (d, 1H), 4.95 (s, 2H), 3.91 (s, 3H)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08778973B2
Source datasetuspto-grants-2014_07
ORD IDord-422791272dfd47eb85b592dd1043ed4e
Source noteuspto-grants-2014_07