2-Chloro-1-fluoro-4-iodobenzene → 3-{3-[1-(3-Chloro-4-fluoro-phenyl)-1-phenyl-meth-(E)-ylidene]-2-oxo-2,3-dihydro-indol-1-ylmethyl}-benzoic acid methyl ester

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Reaction Steps

The title compound was prepared in analogy to Example 5 starting from 2-chloro-1-fluoro-4-iodo-benzene (commercially available) and 3-{[phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (CDCl3, 300 MHz) δppm 8.00 (s, 1H), 7.93 (d, 1H), 7.50 (d, 1H), 7.22-7.42 (m, 9H), 7.09 (dt, 1H), 6.73 (dt, 1H), 6.66 (d, 1H), 6.51 (d, 1H), 4.95 (s, 2H), 3.91 (s, 3H).

Provenance & Evidence