1-Bromo-2-iodobenzene → HCID 51035099, compound

HRID 1623453Notes

Reaction equation

HRID 1623453 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1I.[CH3:9][O:10][C:11](=[O:36])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:20](=[O:29])[C:21]#[C:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:13]=1>>[CH3:9][O:10][C:11](=[O:36])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]2[C:30]3[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=3)/[C:21](=[C:22](\[C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Br:1])/[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)/[C:20]2=[O:29])[CH:13]=1

Participants

3

Reactant 2

HCID 114151-Bromo-2-iodobenzeneHCID 670361553-{[Phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester

Product 1

HCID 51035099HCID 51035099, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-bromo-2-iodobenzene (commercially available) and 3-{[phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (CDCl3, 300 MHz) δppm 8.01 (s, 1H), 7.93 (d, 1H), 7.71 (d, 1H), 7.30-7.53 (m, 11H), 7.04-7.09 (m, 2H), 6.62-7.04 (m, 3H), 6.42 (d, 1H), 6.02 (d, 1H), 4.88-5.05 (m, 2H), 3.91 (s, 3H).

Sources & evidence

ORD record
ord-037b5858ec964761a74fe5127a33e44e
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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