Benzene, 1-iodo-4-(trifluoromethyl)- → HCID 51033889, compound

HRID 1623465Notes

Reaction equation

HRID 1623465 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[CH3:12][O:13][C:14](=[O:40])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([C:29](=[O:39])[C:30]#[C:31][C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:16]=1>>[CH3:12][O:13][C:14](=[O:40])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]2[C:23]3[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=3)/[C:30](=[C:31](/[C:32]3[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=3)\[C:2]3[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=3)/[C:29]2=[O:39])[CH:16]=1

Participants

3

Reactant 2

HCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-HCID 67036326HCID 67036326, compound

Product 1

HCID 51033889HCID 51033889, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-iodo-4-trifluoromethyl-benzene (commercially available) and 3-({[3-(4-chloro-phenyl)-propynoyl]-phenyl-amino}-methyl)-benzoic acid methyl ester. 1H NMR (300 Hz, CDCl3): δppm 3.91 (s, 3H), 4.96 (s, 2H), 6.37 (d, 1H), 6.66-6.71 (m, 2H), 7.08 (t, 1H), 7.26-7.52 (m, 9H), 7.73 (d, 2H), 7.94 (d, 1H), 8.01 (s, 1H).

Sources & evidence

ORD record
ord-67bd6d438b6645b3a4db44123dd60ee7
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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