1,2-Dimethoxyethane → HCID 66789487, compound

Participants

Reaction Conditions

Reaction Steps

To 5-(5-bromo-pyridin-3-yl)-4-chloro-1-methyl-1,3-dihydro-indol-2-one prepared as described in Example 28, (100 mg, 0.30 mmol) was added 3-pyridine boronic acid (CAS#1692-25-7, 47.3 mg, 0.385 mmol), 1,2-dimethoxyethane (3 mL), and 2 M aqueous sodium carbonate (0.385 mL, 0.770 mmol). The reaction mixture was degassed and placed under an argon atmosphere, at which time resin bound tetrakis(triphenylphosphine)palladium(0), specifically polystyrene triphenylphosphine palladium (0) [PS—PPh3-Pd(0) (Biotage), 0.11 mmol/g loading, (135 mg, 0.015 mmol)] was added. The reaction vessel was sealed and was heated by microwave irradiation at 120° C. for 2.5 hours. The reaction mixture was cooled to room temperature, diluted with dichloromethane and filtered through glass wool. The filtrate was further diluted with saturated aqueous sodium bicarbonate and the layers were separated. The aqueous layer was extracted two times with dichloromethane, and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The resulting residue was purified by silica gel flash chromatography (ethanol-dichloromethane, 1 to 8%) to furnish 5-[3,3′]bipyridinyl-5-yl-1-methyl-1,3-dihydro-indol-2-one; HRMS: (ESI) m/z 336.0905 (M+H)+; 1H NMR (400 MHz, DMSO-d6) δ ppm 3.18 (s, 3H), 3.68 (s, 2H), 7.15 (d, J=8.1 Hz, 1H), 7.50-7.60 (m, 2H), 8.20 (t, J=2.1 Hz, 1H), 8.21-8.27 (m, 1H), 8.65 (dd, J=4.7, 1.6 Hz, 1H), 8.68 (d, J=2.0 Hz, 1H), 8.97 (d, J=2.1 Hz, 1H), 9.03 (d, J=2.4 Hz, 1H).

Provenance & Evidence