Potassium Phosphate, Tribasic → HCID 49819733, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-Methyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3H-benzothiazol-2-one (873.5 mg, 3 mmol), 5-Bromo-pyridin-3-ylamine (519 mg, 3 mmol), Pd2(dba)3 (24.7 mg, 0.06 mmol), S—PHOS (62 mg, 0.15 mmol), K3PO4 (1.27 g, 6 mmol) in toluene (15 mL) was heated to 95° C. for overnight. After filtration, concentration, the residue was purified by flash column (MeOH/CH2Cl2, v/v, 1.5-3%) and yielded yellow solid (380 mg). MS (ESI) m/z 258.0 (M+H)+. 1H NMR (400 MHz, CDCl3) δ ppm 3.49 (s, 3H), 3.78 (brs, 2H), 7.10-7.12 (m, 1H), 7.12 (s, 1H), 7.51 (dd, J=8, 2 Hz, 1H), 7.60 (d, J=2 Hz, 1H), 8.08 (d, J=2.6 Hz, 1H), 8.23 (d. J=2 Hz, 1H).

Provenance & Evidence