Dimethylamine, hydrochloride → HCID 59627502, compound

Participants

Reaction Steps

Compound E1 (prepared according to Ex.1) (0.00062 mol) was dissolved in DMF (5 ml). 1-Hydroxy-1H-benzotriazole (0.00186 mol), (3-Dimethylamino-propyl)-ethyl-carbodiimide.hydrochloride (1:1) (0.00186 mol) and N-ethyl-N-(1-methylethyl)-2-propanamine (0.00248 mol) were added, followed by addition of dimethylamine hydrochloride (1:1) (0.00124 mol). The reaction mixture was stirred for 3 hours at r.t. The reaction mixture was poured into water. The mixture was extracted with CHCl3. The organic layer was separated, washed with a 1M HCl solution, then washed with brine and filtered through a hydrophobic frit. The solvents were evaporated under reduced pressure to give a yellow solid residue that was dried further for one hour (in the GeneVac®). The residue was triturated with diethyl ether, filtered off and dried. Yield: 0.245 g of compound E3 (92%).

Provenance & Evidence