Acetic Anhydride → HCID 68469816, compound

HRID 1623582Notes

Reaction equation

HRID 1623582 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][N+:9]([O-])=[C:8]([CH3:13])[C:7]=1[CH3:14])[CH2:2][CH2:3][CH3:4].[C:15]([O:18]C(=O)C)(=[O:17])[CH3:16]>>[C:15]([O:18][CH2:13][C:8]1[C:7]([CH3:14])=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[CH:11]=[CH:10][N:9]=1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 68467290HCID 68467290, compound

Product 1

HCID 68469816HCID 68469816, compoundYield 45.8%

Procedure

To 24.1 g of 4-butoxy-2,3-dimethylpyridine-1-oxide, 44.0 g (4.0 eq.) of acetic anhydride was added, and the mixture was allowed to react for 4 hours at 90° C. Acetic anhydride was distilled off, and then the resulting concentrated residue was purified on a silica gel column, to obtain 13.4 g of 2-acetoxymethyl-3-methyl-4-butoxy-pyridine as an oily matter.

Workup

  1. customto react for 4 hours at 90° C
  2. distillationAcetic anhydride was distilled off
  3. customthe resulting concentrated residue was purified on a silica gel column

Sources & evidence

ORD record
ord-68dbe1cdbc794b9f8d36ac20e3f152b7
Source dataset
uspto-grants-2014_07
Patent number
US08778975B2

Reaction notes

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