Sodium Hydroxide → 4-Butoxy-3-methyl-2-pyridinemethanol

Participants

Reaction Steps

13.4 g of 2-acetoxymethyl-3-methyl-4-butoxy-pyridine was added dropwise to a 25% aqueous solution of sodium hydroxide, and the mixture was allowed to react for one hour at room temperature. The mixture was diluted with toluene, and then the toluene phase was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 8.3 g of 2-hydroxymethyl-3-methyl-4-butoxy-pyridine as an oily matter.

Provenance & Evidence