Sodium Hydroxide → HCID 68465819, compound

HRID 1623591Notes

Reaction equation

HRID 1623591 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([CH2:15][O:16]C(=O)C)[C:10]=1[CH3:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[OH-].[Na+]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([CH2:15][OH:16])[C:10]=1[CH3:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68471774HCID 68471774, compound

Product 1

HCID 68465819HCID 68465819, compoundYield 92.9%

Procedure

19.0 g (0.068 mol, 1.0 eq.) of 4-heptyloxy-2-acetoxymethyl-3-methylpyridine was added dropwise to a 25% aqueous solution of sodium hydroxide at 13 to 25° C., and the mixture was allowed to react for one hour at room temperature, and then extracted with chloroform. The extract was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 15.0 g of 4-heptyloxy-2-hydroxymethyl-3-methylpyridine as a brown oily matter (yield 92.9%).

Workup

  1. customto react for one hour at room temperature
  2. extractionextracted with chloroform
  3. washThe extract was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-6a04967041314f5aa86087b687ba1b53
Source dataset
uspto-grants-2014_07
Patent number
US08778975B2

Reaction notes

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