Thionyl Chloride → HCID 68470112, compound

Participants

Reaction Steps

11.0 g (0.054 mol, 1.0 eq.) of 4-pentyloxy-2-hydroxymethyl-3-methylpyridine was dissolved in 620 mL of chloroform, and 24.9 g (0.281 mol, 4 eq.) of thionyl chloride was added dropwise at 22 to 30° C. Subsequently, the mixture was heated to reflux for one hour, and then concentrated, to obtain 4-pentyloxy-2-chloromethyl-3-methylpyridine as a brown oily matter.

Provenance & Evidence