Thionyl Chloride → HCID 68468113, compound

Participants

Reaction Steps

11.8 g (0.047 mol, 1.0 eq.) of 4-octyloxy-2-hydroxymethyl-3-methylpyridine was dissolved in 600 mL of chloroform, and 28.6 g (0.240 mol, 5.1 eq.) of thionyl chloride was added dropwise at 19 to 27° C. Subsequently, the mixture was heated to reflux for one hour and then concentrated, to obtain 23.8 g of 4-octyloxy-2-chloromethyl-3-methylpyridine as a black oily matter.

Provenance & Evidence