Benzyl Bromide → HCID 67107653, compound

Participants

Reaction Steps

K2CO3 (3.83 g, 27.7 mmol) was added to a stirred solution of 2-hydroxy-5-(1-methylethyl)benzoic acid (may be prepared as described in Description 1; 2.0 g, 11.10 mmol) in acetone (80 ml), followed by the addition of (bromomethyl)benzene (4.75 g, 27.7 mmol). The mixture was refluxed for 12 h and then cooled to room temperature. The mixture was filtered and the filtrate was concentrated to a yellow solid. Flash chromatography over silica gel, using 1:10 ethyl acetate-petroleum ether yielded the title compound as a yellow oil. 1.0 g.

Provenance & Evidence