5-Bromosalicylic acid → HCID 67106908, compound

Participants

Reaction Conditions

Reaction Steps

1-(Bromomethyl)-4-chlorobenzene (592 mg, 2.88 mmol) was added in a single charge to a stirred suspension of 5-bromo-2-hydroxybenzoic acid (250 mg, 1.15 mmol) and potassium carbonate (478 mg, 3.46 mmol) in acetone (40 ml) under nitrogen at 20° C. The reaction mixture was stirred at 55° C. for 18 h. The organic phase was evaporated and the residue was washed with water (25 ml), extracted with ethyl acetate (30×3 ml) and evaporated in vacuo to yield the title compound as an off-white solid. 320 mg.

Provenance & Evidence