5-Bromosalicylic acid → HCID 67107238, compound

Participants

Reaction Conditions

Reaction Steps

4-(Bromomethyl)benzonitrile (318 mg, 1.622 mmol) was added in a single charge to a stirred suspension of 5-bromo-2-hydroxybenzoic acid (160 mg, 0.74 mmol) and potassium carbonate (204 mg, 1.48 mmol) in acetone (40 ml) at 20° C. The reaction mixture was stirred at 55° C. for 18 h. The organic phase was evaporated and the residue was washed with water (25 ml), extracted with ethyl acetate (3×30 ml) and evaporated in vacuo to yield the title compound as an off-white solid. 300 mg.

Provenance & Evidence