5-Bromosalicylic acid → HCID 67107679, compound

Participants

Reaction Conditions

Reaction Steps

Neat 1-(bromomethyl)-3-methoxybenzene (510 mg, 2.53 mmol) was added in one charge to a stirred suspension of 5-bromo-2-hydroxybenzoic acid (250 mg, 1.15 mmol) and potassium carbonate (318 mg, 2.304 mmol) in acetone (40 ml) under nitrogen at 20° C. The reaction mixture was stirred at 55° C. for 16 h. The organic phase was evaporated and the residue was washed with water (25 ml), extracted by ethyl acetate (3×30 ml) and evaporated in vacuo to yield the title compound as an off-white solid. 430 mg.

Provenance & Evidence