5-Bromosalicylic acid → HCID 67107147, compound

Participants

Reaction Conditions

Reaction Steps

2-(Bromomethyl)benzonitrile (397 mg, 2.027 mmol) was added in one charge to a stirred suspension of 5-bromo-2-hydroxybenzoic acid (200 mg, 0.92 mmol) and potassium carbonate (255 mg, 1.84 mmol) in acetone (40 ml) under nitrogen at 20° C. The reaction mixture was stirred at 55° C. for 16 h. The organic phase was evaporated and the residue was washed with water (25 ml), extracted with ethyl acetate (100 ml) and evaporated in vacuo to yield the title compound as an off-white solid. 350 mg.

Provenance & Evidence