4-Toluenesulfonyl chloride → Methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate

Participants

Reaction Steps

A mixture of methyl 2,5-dihydroxybenzoate (1.5 g, 8.92 mmol), potassium carbonate (7.50 g, 54.2 mmol), and dry acetone (100 ml) was stirred at room temperature for 30 min. To the mixture was added TsCl (1.72 g, 9.00 mmol) portionwise and the mixture was refluxed for 7 h. The reaction mixture was used in the next step directly.

Provenance & Evidence