反应详情

Methyl 5-{[(4-methylphenyl)sulfonyl]oxy}-2-[(phenylmethyl)oxy]benzoate (may be prepared as described in Description 37; 2.5 g, 6.06 mmol) was boiled with potassium hydroxide (2.38 g, 42.4 mmol) in a mixture of ethanol (60 ml) and water (15 ml) for 4 h. After the ethanol had been evaporated, the aqueous solution was washed with ethyl acetate (20 ml) and acidified with concentrated HCl. The mixture was extracted with ethyl acetate (3×30 ml). The organic phase was washed with saturated brine (25 ml), dried over sodium sulphate and evaporated in vacuo to yield the title compound as a yellow oil. 1.35 g.

1. customAfter the ethanol had been evaporated
2. washthe aqueous solution was washed with ethyl acetate (20 ml)
3. extractionThe mixture was extracted with ethyl acetate (3×30 ml)
4. washThe organic phase was washed with saturated brine (25 ml)
5. dry with materialdried over sodium sulphate
6. customevaporated in vacuo