反应详情

Methyl 5-{[(4-methylphenyl)sulfonyl]oxy}-2-[(phenylmethyl)oxy]benzoate (may be prepared as described in Description 75; 22.0 g, 53.3 mmol) was boiled with potassium hydroxide (20.95 g, 373 mmol) in a mixture of ethanol (320 ml) and water (80 ml) overnight. After the ethanol had been evaporated, the aqueous solution was washed with ethyl acetate (500 ml), and then acidified with concentrated HCl. The mixture was extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over sodium sulfate, and evaporated in vacuo to yield the title compound as a yellow oil. 14 g.

1. customAfter the ethanol had been evaporated
2. washthe aqueous solution was washed with ethyl acetate (500 ml)
3. extractionThe mixture was extracted with ethyl acetate
4. washThe organic phase was washed with saturated brine
5. dry with materialdried over sodium sulfate
6. customevaporated in vacuo