Cesium carbonate → HCID 67107114, compound

Participants

Reaction Steps

Caesium carbonate (574 mg, 1.76 mmol) was finely ground in a nitrogen-filled glovebox and weighed into an oven-dried Schlenk flask. The flask was quickly capped with a rubber septum and purged with argon. Pd2(dba)3 (2.88 mg, 3.15 μmol) and BINAP (5.88 mg, 9.44 μmol) were added into the flask, followed by benzyl 2-(benzyloxy)-5-bromobenzoate (may be prepared as described in Description 4; 500 mg, 1.26 mmol), 1-methylpiperazine (126 mg, 1.26 mmol), and toluene (10 ml). The solution was refluxed for 10 h. The solution was then cooled to room temperature, diluted with ether, filtered, and concentrated in vacuo to yield the title compound which was not further purified. 100 mg.

Provenance & Evidence