Dimethylamine → Methyl 5-[(dimethylamino)sulfonyl]-2-hydroxybenzoate

Participants

Reaction Conditions

Reaction Steps

A 33% solution of dimethylamine (1.53 ml, 9.97 mmol) in water was added dropwise to methyl 5-(chlorosulfonyl)-2-hydroxybenzoate (may be prepared as described in Description 60; 500 mg, 2.00 mmol) in dichloromethane (20 ml) at 25° C., and the mixture was allowed to stir at 25° C. for 2 h. The mixture was then concentrated in vacuo to give the yield the title compound as a crude product. 260 mg.

Provenance & Evidence