Benzyl Bromide → Methyl 5-(dimethylsulfamoyl)-2-phenylmethoxybenzoate

Participants

Reaction Steps

K2CO3 (139 mg, 1.00 mmol) was added to a stirred solution of methyl 5-[(dimethylamino)sulfonyl]-2-hydroxybenzoate (may be prepared as described in Description 61; 260 mg, 1.00 mmol) in acetone (30 ml), followed by the addition of (bromomethyl)benzene (172 mg, 1.00 mmol). The mixture was heated to reflux for 16 h, and then cooled to room temperature. The mixture was filtered, and the filtrate was concentrated to yield the title compound as a colourless oil. 300 mg.

Provenance & Evidence