Morpholine → Methyl 2-hydroxy-5-(4-morpholinylsulfonyl)benzoate

Participants

Reaction Conditions

Reaction Steps

Morpholine (174 mg, 2.00 mmol) was added dropwise to methyl 5-(chlorosulfonyl)-2-hydroxybenzoate (may be prepared as described in Description 63; 500 mg, 2.00 mmol) in dichloromethane (20 ml) at 25° C., and the mixture was allowed to stir at 25° C. for 2 h. The mixture was then concentrated in vacuo to yield the crude title compound. 350 mg.

Provenance & Evidence