Cesium carbonate → HCID 67107213, compound

Participants

Reaction Conditions

Reaction Steps

2-{[2-({4-[(Phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}oxy)ethyl]oxy}ethyl 4-methylbenzenesulfonate (may be prepared as described in Description 76; 500 mg, 0.89 mmol) was dissolved in N,N-dimethylformamide (10 ml). Di-tert-butyl iminodicarbonate (193 mg, 0.89 mmol) and Cs2CO3 (290 mg, 0.89 mmol) were added. The reaction mixture was heated at 60° C. for 3 h. After cooling to room temperature, the reaction mixture was diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with water, brine, dried over Na2SO4, and concentrated under reduced pressure to yield the title compound as an oil. 360 mg.

Provenance & Evidence