5-Bromosalicylic acid → HCID 67106784, compound

Participants

Reaction Conditions

Reaction Steps

Neat 4-(bromomethyl)-1,2-difluorobenzene (1526 mg, 7.37 mmol) was added over 1 min to a stirred suspension of 5-bromo-2-hydroxybenzoic acid (800 mg, 3.69 mmol) and potassium carbonate (1274 mg, 9.22 mmol) in acetone (60 ml) in air at room temperature. The reaction mixture was stirred at 70° C. overnight. After filtering, the filtrate was evaporated to give a solid, which was dried in vacuo to yield the title compound as a white solid. 2.0 g.

Provenance & Evidence