5-Bromosalicylic acid → HCID 67106784, compound

Participants

Reaction Steps

To a stirred solution of 5-bromo-2-hydroxybenzoic acid (1.8 g, 8.29 mmol) in acetone (50 ml) at room temperature was added potassium carbonate (2.87 g, 20.74 mmol) followed by 4-(bromomethyl)-1,2-difluorobenzene (2.34 ml, 18.25 mmol). The mixture was stirred at room temperature for 30 min and then heated to reflux for 15 hr. The solid was filtered off and washed with acetone (3×50 ml). The organic layer was evaporated under reduced pressure and the oil was purified by chromatography using a silica cartridge, eluting with 0-15% ethyl acetate/isohexane to give a clear oil, which solidified on standing to yield the title compound. 3.9 g.

Provenance & Evidence