5-Bromosalicylic acid → HCID 67107475, compound

Participants

Reaction Steps

To a solution of 5-bromo-2-hydroxybenzoic acid (2.5 g, 11.52 mmol) in acetone (100 ml) was added potassium carbonate (3.98 g, 28.8 mmol) and 1-(bromomethyl)-2,4-difluorobenzene (3.25 ml, 25.3 mmol). The mixture was heated to reflux for 4 hours. On cooling the mixture was filtered to remove the carbonate, the solid was washed with acetone (50 ml). The organics were evaporated under reduced pressure to give a white solid 5.39 g. No attempt was made to purify this compound it was taken on as is.

Provenance & Evidence