Methanol → HCID 86668206, compound

Participants

Reaction Steps

Lithium hydroxide (0.75 g, 31.4 mmol), methanol (25 ml) and water (25 ml) were added to a solution of (4-fluorophenyl)methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-formylbenzoate (may be prepared as described in Description 104; 4 g, 10.46 mmol) in tetrahydrofuran (100 ml). The mixture was stirred at room temperature overnight. The mixture was evaporated to half volume, diluted with water (100 ml) and acidified with 1M aqueous hydrochloric acid to adjust the pH to 1. The mixture was stirred at room temperature and the solid formed was filtered, washed with water (50 ml) and air dried under vacuum to yield the title compound as a white solid. 2.85 g.

Provenance & Evidence