反应详情

温度

50 °C

To a solution of methyl 2-hydroxy-5-(4-morpholinylcarbonyl)benzoate (may be prepared as described in Description 108, 270 mg, 1.02 mmol) in acetone (3 ml) was added cesium carbonate (663 mg, 2.04 mmol) and 4-fluorobenzyl bromide (0.16 ml, 1.32 mmol). The mixture was heated at 50° C. for 2 hours. The solvent was removed in vacuo and the residue partitioned between ethyl acetate (15 ml) and water (5 ml). The organic layer was dried and the solvent removed in vacuo and the residue purified by column chromatography (silicon, 4:1 ethyl acetate/cyclohexane) to give the title compound as a yellow gum. 96 mg.

1. customThe solvent was removed in vacuo
2. customthe residue partitioned between ethyl acetate (15 ml) and water (5 ml)
3. customThe organic layer was dried
4. customthe solvent removed in vacuo
5. customthe residue purified by column chromatography (silicon, 4:1 ethyl acetate/cyclohexane)