1,2-Dichloroethane → HCID 69936802, compound

Participants

Reaction Steps

A solution of 5-(1-methylethyl)-2-[(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 3; 300 mg, 1.11 mmol), pyridin-3-amine (157 mg, 1.67 mmol), EDC (319 mg, 1.67 mmol) and HOBT (255 mg, 1.665 mmol) in DMF (5 mL) was stirred at room temperature overnight. The reaction mixture was poured into water (20 ml), filtered and the solid was washed with water and dried to yield a white solid. The crude product was purified by silica gel chromatography, eluting with petroleum ether:ethyl acetate (3:1) to yield the title compound as a white solid. 140 mg.

Provenance & Evidence