1,2-Dichloroethane → HCID 67107488, compound

Participants

Reaction Steps

Neat HOBT (94 mg, 0.62 mmol) was added in one charge to a stirred solution of 2-[(phenylmethyl)oxy]-5-(1-pyrrolidinylcarbonyl)benzoic acid (may be prepared as described in Description 55; 200 mg, 0.62 mmol), 3-pyridinamine (57.9 mg, 0.62 mmol) and EDC (118 mg, 0.62 mmol) in N,N-dimethylformamide (5 ml) under nitrogen at room temperature. The reaction mixture was stirred at room temperature for 4 h. The mixture was diluted with water (50 ml). The precipitate was collected by filtration, washed with ether (5 ml), and dried to yield the title compound as a white solid. 88 mg.

Provenance & Evidence