HCID 67107213, compound → HCID 69936609, compound

Participants

Reaction Conditions

Reaction Steps

Bis(1,1-dimethylethyl) (2-{[2-({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}oxy)ethyl]oxy}ethyl)imidodicarbonate (may be prepared as described in Description 77; 340 mg, 0.56 mmol) was treated with trifluoroacetic acid/dichloromethane (v/v 40%, 10 ml). The mixture was stirred at 25° C. for 1 h. The solvent was removed under reduced pressure. The residue was purified twice by reverse phase HPLC using a gradient of acetonitrile and 0.1% aqueous ammonia as the eluent. Evaporation of the product-containing fractions yielded the title compound as a white solid. 86 mg.

Provenance & Evidence