1,2-Dichloroethane → HCID 68108534, compound

Participants

Reaction Conditions

Reaction Steps

Neat pyridin-3-amine (82 mg, 0.87 mmol) was added in one charge to a stirred solution of 5-bromo-2-{[(2-fluorophenyl)methyl]oxy}benzoic acid (may be prepared as described in Description 85; 200 mg, 0.58 mmol), EDC (223 mg, 1.16 mmol) and HOBT (178 mg, 1.16 mmol) in dimethylformamide (3 ml) in air at room temperature. The reaction mixture was stirred at 25° C. overnight. Water (25 ml) was added into the reaction mixture. The precipitate was filtered, washed with water (15 ml), and dried in vacuum to obtain crude product, which was purified with Prep-TLC (eluate: dichloromethane:methanol=25:1) to yield the title compound as a white solid. 67 mg.

Provenance & Evidence