1,2-Dichloroethane → HCID 67107332, compound

Participants

Reaction Steps

Neat 1H-pyrazol-4-amine (49.0 mg, 0.59 mmol) was added in one charge to a stirred solution of 2-[(phenylmethyl)oxy]-5-(4-pyridinyl)benzoic acid (may be prepared as described in Description 79; 150 mg, 0.49 mmol), EDC (283 mg, 1.47 mmol) and HOBT (226 mg, 1.47 mmol) in dimethylformamide (4 ml) in air at room temperature. The reaction mixture was stirred at room temperature overnight. 30 ml water was added, and the mixture was extracted with ethyl acetate (70 ml×2). The organic layers were combined, dried over MgSO4, and concentrated in vacuo. The residue was further purified by pre-HPLC (Gilson GX-281; Shimadzu 15 μm 250*20 mm; A: 10 mMol NH4HCO3/Water; B: CH3CN) to yield the title compound as a white solid. 50 mg.

Provenance & Evidence