Sodium Carbonate → HCID 69936544, compound

HRID 1623814Notes

Reaction equation

HRID 1623814 reaction equation
[N:1]1[CH:6]=[CH:5][C:4](B(O)O)=[CH:3][CH:2]=1.C([O-])([O-])=O.[Na+].[Na+].Br[C:17]1[CH:18]=[CH:19][C:20]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[C:21]([CH:31]=1)[C:22]([NH:24][C:25]1[CH:30]=[CH:29][N:28]=[N:27][CH:26]=1)=[O:23]>COCCOC.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:34]1([CH2:33][O:32][C:20]2[CH:19]=[CH:18][C:17]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)=[CH:31][C:21]=2[C:22]([NH:24][C:25]2[CH:30]=[CH:29][N:28]=[N:27][CH:26]=2)=[O:23])[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 2734379(Pyridin-4-yl)boronic acidHCID 51357233HCID 51357233, compound

Product 1

HCID 69936544HCID 69936544, compound

Reagents, catalysts & solvents 2

HCID 178418397HCID 178418397, compoundCatalystHCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
140 °C

Procedure

Pyridine 4-boronic acid (35.2 mg, 0.29 mmol), 1M Na2CO3 (0.52 ml, 0.52 mmol) and tetrakis(triphenylphosphine)palladium(0) (18 mg, 6 mol %) were added to a solution of 5-bromo-2-[(phenylmethyl)oxy]-N-4-pyridazinylbenzamide (may be prepared as described in Example 6; 100 mg, 0.26 mmol) in 1,2-dimethoxyethane (3 ml). The solution was heated at 140° C. in microwave for 25 minutes. The solvent was removed in vacuo and the residue purified by MDAP to yield the title compound as an off white solid. 22 mg.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue purified by MDAP

Sources & evidence

ORD record
ord-2ed4c46eb08344fab8e189082c53b70f
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

Loading…