HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 5-Bromo-2-{[(4-fluorophenyl)methyl]oxy}-N-4-pyridazinylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Aminopyridazine | HCID 298492 | — |
| Reactant | 5-Bromo-2-[(4-fluorobenzyl)oxy]benzoic acid | HCID 8706889 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Bromo-2-{[(4-fluorophenyl)methyl]oxy}-N-4-pyridazinylbenzamide | HCID 67107358 | — |
Reaction Steps
Diisopropylethylamine (1.61 ml, 9.23 mmol), 4-pyridazinamine (0.53 g, 5.54 mmol) and HATU (2.63 g, 6.92 mmol) were added to a solution of 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}benzoic acid (may be prepared as described in Description 87; 1.5 g, 4.61 mmol) in N,N-dimethylformamide (10 ml). The mixture was stirred for 2 hours and the solid was filtered and washed with ethyl acetate to yield the title compound as a white solid. 658 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08778939B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-111e43241f9c4dd1afa034082bf0d761 |
| Source note | uspto-grants-2014_07 |