Diisopropylethylamine → HCID 67107764, compound

Participants

Reaction Steps

4-Pyridazinamine (0.42 g, 4.37 mmol), HATU (2.22 g, 5.83 mmol) and diisopropylethylamine (1.53 ml, 8.74 mmol) were added to a solution of 5-bromo-2-{[(3,4-difluorophenyl)methyl]oxy}benzoic acid (may be prepared by Description 89; 1 g, 2.91 mmol) in N,N-dimethylformamide (25 ml). The mixture was stirred at room temperature for 2 hours. The mixture was diluted with ethyl acetate (200 ml), shaken and allowed to stand for 5 min. The precipitate was filtered, washed with water (25 ml) and ethyl acetate (50 ml), and dried under vacuum to yield the title compound as a white solid. No further purification was carried out. 900 mg.

Provenance & Evidence