Pyridine → HCID 88593266, compound

Participants

Reaction Steps

Pyridine (0.69 ml, 8.56 mmol) and hydroxylamine hydrochloride (119 mg, 1.71 mmol) were added to a solution of 2-{[(4-fluorophenyl)methyl]oxy}-5-formyl-N-3-pyridinylbenzamide (may be prepared as described in Example 82; 300 mg, 0.86 mmol) in methanol (10 ml) and the mixture was stirred at room temperature for 30 min. The mixture was evaporated under reduced pressure to half volume. The mixture was diluted with water (20 ml) and filtered. The solid was washed with cold water (20 ml)/cold methanol (5 ml) and dried under vacuum to yield the title compound as a white solid. 220 mg.

Provenance & Evidence