反应详情

温度

100 °C

To a microwave vial was added 5-bromo-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide (may be prepared as described in example 2; 200 mg, 0.52 mmol), 1,4-dioxane (2 ml), 4-pyridinylboronic acid (64.1 mg, 0.52 mmol), 1M sodium carbonate (1.04 mL, 1.04 mmol) and tetrakis(triphenylphosphine)palladium(0) (36.2 mg, 0.03 mmol). The vial was sealed and heated to 100° C. for 30 min under microwave conditions. The mixture was evaporated under reduced pressure and the residue was purified using MDAP to yield the title compound. 41 mg.

1. customThe vial was sealed
2. customThe mixture was evaporated under reduced pressure
3. customthe residue was purified