Sodium Carbonate → HCID 69936331, compound

Participants

Reaction Conditions

Reaction Steps

To a microwave vial was added 5-bromo-N-(5-fluoro-3-pyridinyl)-2-[(phenylmethyl)oxy]benzamide (may be prepared as described in Example 98; 200 mg, 0.50 mmol), 1,4-dioxane (2 ml), 4-pyridinylboronic acid (73.5 mg, 0.60 mmol), 1M sodium carbonate (1.00 ml, 1.00 mmol) and tetrakis(triphenylphosphine)palladium(0) (34.6 mg, 0.03 mmol). The vial was sealed and heated to 130° C. for 30 min under microwave conditions. The mixture was evaporated under reduced pressure and the residue was purified using MDAP (twice) to yield the title compound. 9 mg.

Provenance & Evidence